The UIU Plug-ins 2.0 with SCCM (as of UIU 2.2.2.x) now requires the .NET 4.6 Framework.
Symptoms: Automatic generation of the default UIU packages in SCCM could generate duplicate packages, particularly in multi-site implementations. The process could also potentially affect existing UIU packages during a plug-in update action (e.g. changing the source location), rendering them invalid. Resolution: The UIU Plug-in Manager will not create new packages for UIU upon installation and will no longer refresh existing UIU packages when a plug-in update is administered.
Details: UIU code has been updated to accomodate the released Current Branch of SCCM.